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This can cause precipitation of calcium and magnesium

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A.RuusuvuoriE.LahtinenH.LamsaK.et al (1999)

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In the colon cancer case it is mentioned that if the HOTYR would reach the colon in a distribution volume of around 250 ml, it would result in a concentration of approximately 72 mol/l, a value that induced a 50% inhibition of cell proliferation