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An increase in ROS levels has also been shown to increase nonspecific cation conductance of the plasma membrane, thus affecting the osmotic balance of the cell

Oeda T, Henkel R, Ohmori H, Schill WB

The protective effect of NTZ was dose-dependent, and the findings observed with the high-dose NTZ were similar to those obtained with the ER-stress inhibitor (4-PBA)