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10.13847/j.cnki.lnmu.2021.05.003 41 HeY

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Extended cycles of 8 weeks are employed when research objectives need longer finding periods

For example, ROS-responsive nanoparticles self-assembled from a hybrid platinum prodrug CPT-Pt (IV), ROS-sensitive polymer, and mPEG2k-DSPE can accumulate at tumor sites and release cisplatin and CPT, leading to DNA double-strand damage, ultimately activating the cGAS-STING pathway, inducing DCs maturation and increasing tumor infiltration of CD8 + T cells (230)