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The ferroptosis pathways within nerve cells include iron homeostasis regulation, cystine/glutamate (Glu) reverse transporter (system xc ), glutathione (GSH)/glutathione peroxidase 4 (GPX4), and lipid peroxidation

A study in mice and human tissue, published in Nature , shows that cancer cells can break it down and use it as fuelparticularly the cysteine it containspromoting tumour growth and survival

Boros BD, Greathouse KM, Gentry EG, Curtis KA, Birchall EL, Gearing M, et al

found that increased GPx1 levels significantly increased the resistance of breast cancer T47D cells to doxorubicin partially by interfering with the activation of the sphingomyelin-ceramide pathway [85]