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FDA Warning Letters The FDA issued a warning letter to an Illinois manufacturer after it isolated at least nine samples of Bacillus cereus, a bacterium that causes food poisoning, in its finished products and at least five samples taken from the manufacturing environment

Animal studies showed thyroid C-cell tumors at exposures much higher than clinical doses

Studies have shown that local COX-2 overexpression increases the number of CD90 + mouse skeletal stem cells (mSSCs) at the fracture site and targets CD90 + mSSCs to enhance canonical Wnt signal transduction, which results in the promotion of intramembranous osteogenesis and inhibition of intrachondral osteogenesis

De SantisMDi MatteoBChisariECincinelliGAngelePLattermannCet al