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Furthermore, clinical data indicated that anti-angiogenic treatments are not always efficient in normalizing the tumor vasculature and could lead to therapy resistance due to the presence of compensatory angiogenic pathways (151)

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[DOI] [Google Scholar] 80.Loffredo E., Traversa A., Senesi N

The dysregulation in the signals within a group of cells leads to the uncontrolled growth, and invasion that either directly intrudes upon and destroys adjacent tissue or metastasizes and spread to other location in the body through the lymphatic system or the blood stream