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Brcic, et al

In glioblastoma, gastric and head and neck tumors expressing both c-Met and HGF, the mutation of MET was found and correlated with poor prognosis in patients

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Headache, particularly at initiation Mild anxiety or restlessness with some compounds Nasal irritation (intranasal administration) Sleep disturbance if dosed too close to bedtime Rare: Mood changes or emotional lability Dihexa (PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a potent hepatocyte growth factor (HGF) receptor agonist originally developed at Washington State University

Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis