The UPS is the primary intracellular non-lysosomal pathway for protein degradation, consisting of substrates, ubiquitin molecules, ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), ubiquitin-ligase enzymes (E3), 26S proteasomes, and deubiquitinating enzymes (DUBs) 15,19,20,21
Subsequently, mevalonate is modified to produce isopentenyl pyrophosphate (IPP), which is finally converted to the direct precursors of cholesterol, squalene, and lanosterol ( de novo synthesis, as it is not permeable to circulating lipoprotein-bound cholesterol ( Once available, cholesterol is transported to mitochondria by proteins such as the 18 kDa translocator protein (TSPO) and the steroidogenic acute regulatory protein (StAR) ( Regarding the local synthesis of P4, the human CNS produces this hormone from prenatal stages through postnatal life
I am betting on pseudoscientific nonsense
Here is the honest evidence status up front, because it shapes everything that follows: the human data on this combination is essentially non-existent
Silic-Benussi M, Cannizzaro E, Venerando A, Cavallari I, Petronilli V, La Rocca N, Marin O, Chieco-Bianchi L, Di Lisa F, D'Agostino DM, Bernardi P, Ciminale V
