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Acknowledgments The authors thank all the members in the JLs research group especially Qiang Chen for helpful discussions on the manuscript

Acidosis may damage the epithelium and alter permeability, as hyperpermeability has been reported in both cattle and swine mucosa with acidosis [128,129]

Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease

L-Glycine An amino acid that supports metabolic and cellular health

Many studies have highlighted the role of dysbiosis in obesity [48, 49], with some studies indicating it could be modulated by several months on an LFD [50, 51]