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An RCT in 50 infertile men found that NAC (600 mg/day for 3 months) significantly improved sperm concentration, motility, and morphology and reduced oxidative stress markers (Ciftci et al., Urology, 2009) [69]

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Safety Research Priorities Comprehensive long-term safety studies are critically needed, particularly given concerns about potential effects on cancer development and progression

Research in bleomycin-induced pulmonary fibrosis models demonstrates that FOXO4-DRI treatment leads to substantially milder pathological changes and reduced collagen accumulation compared to untreated controls