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A comprehensive review of seven studies with well over 1.5 million participants found a 26% increased risk of accelerating CKD progression with habitual use of high-dose NSAIDs (Nderitu 2013)

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The alternative path: if the patient had an inadequate initial response, a repeat injection after 14 days can be considered medically necessary when the provider documents a rationale for a different approach, level, or medication at the subsequent injection

You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses