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Hydroquinone inhibits melanin production, and discontinuing its use allows normal melanin synthesis to resume, particularly with exposure to sunlight

Chronic stress increases inflammation and disrupts gut function

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Exaggerated release of corticotropin-releasing factor (CRF) contributes to greater adrenocorticotropic hormone (ACTH) secretion and a subsequent elevation of circulating glucocorticoids (i.e., cortisol) (168)