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The 2025 narrative review noted that despite the volume of preclinical work, well-controlled human trial data are scarce, and the regenerative findings should be interpreted accordingly (PMID 40789979)
Given that glutathione affects the production of melanin (the pigment that gives the human skin, hair and eyes their color) there are theoretical concerns about the long term skin cancer risk
Harsh cleansing compromises barrier function and increases sensitivity to active ingredients
One is that GSSG and GS-X produced in cardiomyocytes are pumped out by multidrug resistance protein 1 (MRP1), preventing GSSG or GS-X accumulation in cardiomyocytes [33, 34], and subsequently enter the -glutamyl cycle
