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TB-500 / T4 also rests mostly on decades of preclinical work, but the T4 compound class has reached human clinical study in at least one delivery context: a topical T4 ophthalmic candidate (RGN-259) was evaluated in human Phase 2 trials for corneal/dry-eye endpoints (Crockford et al., Ann N Y Acad Sci 2010)

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PubMed 18068698 TB-4 / TB-500 product mislabeling documented bidirectional mislabeling between full-length TB-4 (43 aa) and the TB-500 fragment (residues 1723) in marketed peptide products: Esposito M et al

Other side effects: Other side effects may occur such as headache, confusion, and changes in heart rate

Early research demonstrated the enhanced ROS generation of PDTCDT synergistic therapy that chemodynamic agent FePt nanoparticles loaded on BP could spontaneously produce additional ROS during the treatment (Yao et al., 2020)