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This last mechanism involves the reduction of glucose by the action of aldose-reductase to sorbitol, which is further converted to fructose by the action of sorbitol dehydrogenase

While most observational research shows a protective association of folate against colorectal cancer development, it has been suggested that high doses of supplemental folic acid may actually accelerate tumor growth in cancer patients (129)

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Seifi HS, Shelp BJ (2019) Spermine differentially refines plant defense responses against biotic and abiotic stresses

It promotes glucose uptake by directly upregulating GLUT1/3, promotes glycolysis by upregulating hexokinase 2 (HK2), and promotes lipogenesis by directly interacting with SREBP