Lack of Vitamin B12 can create anaemias
and patients with pernicious anemia who have optic neuropathy COBALAMIN (Vitamin B12) Deficiency Causes Vegetarians (dietary deficiency) Older adults: atrophic gastritis affects 10% 30% and leads to decrease in hydrochloric acid secretion in the stomach and decreased absorption of Vitamin B12 The liver can store up to six years worth of Vitamin B12 so deficiencies are rare Effects of deficiency Megaloblastic anaemia (pernicious anaemia) Progressive demyelination of nerve cells Elevation in levels of circulating homocysteine that leads to production of defective collagen and elastin with a negative impact on arteries, bone and skin Deep vein thrombosis is associated with homocysteinemia that causes the activation of the intrinsic coagulation cascade Symptoms include fatigue, weakness, constipation, loss of appetite and weight loss Numbness, tingling of the feet imbalance, depression, confusion, dementia, poor memory and glossitis
Why ferritin matters: Ferritin can drop long before hemoglobin does, which means you can be iron-deficient and feel awful while your standard iron panel still looks normal. This is called non-anemic iron deficiency, and it is one of the most under-diagnosed causes of fatigue, hair loss, and exercise intolerance particularly in menstruating women, athletes, and vegetarians
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