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PMC 1033307

But a huge number of meat eaters are also deficient and likely dont know it B12 is absorbed through the stomach, and our ability to assimilate it through the stomach wall decreases with age, as well as due to any stomach issues like IBS, Crohns, and Celiac Disease, and medications that impact the stomach like metformin, antacids, PPIs, and ibuprofen

It has many instant benefits: it's a great solvent, penetration enhancer , creates cosmetically elegant, light formulas , great astringent and antimicrobial

The mechanism of regulation of each isoforms by different stresses and developmental stages is yet to be completely understood

That versatility across different research contexts is what's made it such a go-to reference compound over the years