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During wound healing, it can be removed from existing extracellular proteins by proteolysis and used as a chemical attractant for inflammatory and endothelial cells It can increase the production of messenger RNA in collagen, elastin, proteoglycans and glycosaminoglycans in fibroblasts

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In some embodiments, the otoprotectant is any one of the following compounds: In some embodiments, the otoprotectant is a compound comprising a thiophene-carboxamide moiety core structure of Formula (I): In some embodiments, the otoprotectant is a compound comprising a thiophene-carboxamide moiety core structure of Formula (II): wherein ring A is optionally attached and is a 5-7 membered ring that is aromatic or non-aromatic and can contain one more heteroatoms (N, O, or S atoms)