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Proc Natl Acad Sci USA 2002

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Removing it reduces IGFBP affinity by approximately 90%, increasing the free fraction of the peptide available for IGF1R engagement

One is a tetrahedral geometry with three nitrogen atoms and one oxygen atom from three histidine ligands, imitating the active site of CA, and the other is a distorted trigonal bipyramidal geometry also coordinated by the histidine ligands