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Supplementary Figure 2 GSH metabolism signal scoring using ssgsea, UCell, and Scoring algorithms, visualized on UMAP landscapes of normal pancreatic tissue and pancreatic cancer tissue

Given the close collaboration between astrocytes and neurons in energy metabolism [135], it is plausible that lactylation, triggered by the accumulation of lactate, may play a supportive role in bolstering neuronal energy metabolism and be a crucial factor in maintaining the metabolic equilibrium necessary for the proper functioning of neural networks

Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells

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