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NF-E2-related factor-2 (Nrf2) is a transcription factor that regulates the expression of antioxidant and phase II detoxifying enzymes

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For example, endothelium-derived NO directly suppresses the electrical excitability of VSMCs by inhibiting the action of T-type and L-type voltage-gated Ca 2+ channels in small arteries, and reduced NO availability can trigger transient depolarization in normally quiescent VSMCs leading to vasospasm (Smith et al., 2020)

Peptides, by contrast, are studied for more targeted biological signaling pathways

The figure 157 is its sequence