Two of these case series suggest that dosage may be of importance, with individual differences and higher doses more effective than lower ones where dose was titrated up (dosage ranges 6001800 mg per day)
Green R, Allen LH, Bjrke-Monsen A-L, et al

Disclosure of interest: The authors of this study have nothing to disclose Poster Session I - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.04 - STROKE COMPLICATIONS P403 - ESOC25-2347 POST-STROKE EPILEPSY IN THE ERA OF ADVANCED REPERFUSION THERAPIES Catarina Guedes Vaz 1 , Alexandre Dias 2,3 , Ricardo Varela 1 , Isabel Silva 3 , Ana Moutinho 2,3 , Pedro Castro 4 , Bruno Castro 4 , Carla Oliveira 2,5 , Henrik Zetterberg 6 , Johan Gobom 6 , Manuel Correia 1,3 , Rui Magalhes 3 , Lus Maia 1,2,3 1 Servio de Neurologia, Centro Hospitalar Universitrio de Santo Antnio, ULSdSA, Porto, Portugal, 2 Instituto de Investigao e Inovao em Sade (i3S), Universidade do Porto, Porto, Portugal, 3 Instituto de Cincias Biomdicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal, 4 Servio de Neurologia, Centro Hospitalar Universitrio de So Joo, ULSdSJ, Porto, Portugal, 5 Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal, 6 Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg (UGOT), Gothenburg, Sweden Background and Aims: Post-stroke epilepsy (PSE) is a significant comorbidity in stroke survivors

The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity
This can sometimes lead to what's known as a Herxheimer reaction, or a 'healing crisis.' As toxins are mobilized from tissues and flushed out of the body, they can cause temporary symptoms like headaches, fatigue, skin rashes, andyou guessed itdigestive upset