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It acts as a cofactor for methionine synthase, which is required for the production of SAMe, the methyl donor involved in synthesis of serotonin and dopamine

And, since B12 is a water-soluble vitamin, your body can flush out any excess, making it safe to supplement your diet with B12

A B12 deficiency can happen due to age, low absorption, low IF levels, or diet

The most common negative side effect for first-time topical rapamycin users is dry skin

At clinical doses under supervision, the most common side effects are mild nausea in the first week (typically resolves by day 7 to 10), injection site reactions (redness, minor swelling, localized soreness lasting 24 hours), and occasional transient fatigue or mild headache in the first few days