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According to the American Academy of Orthopaedic Surgeons, it may take several weeks to notice an improvement [2]

GLP-1 receptor agonists like Saxenda (liraglutide, NICE TA664) and Wegovy (semaglutide, NICE TA875) may be considered for patients who meet specific criteria and have not achieved adequate weight loss with other interventions

Taken together, targeting the gut microbiota to reduce inflammation associated with PAIS appears as a relevant strategy, already proposed for MS (237), which is worth considering in future studies