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In some embodiments, local otic delivery of the auris formulations or compositions described herein allows for controlled release of active agents to auris structures and overcomes the drawbacks associated with systemic administration (e.g., low bioavailability of the drug in the endolymph or perilymph, variability in concentration of the drug in the external, middle and/or internal ear)

This information is intended for educational purposes and does not replace individualized medical advice

There is no accumulation concern with either formulation at standard injectable doses

Then, the 20 ug of isolated soluble proteins was mixed with 5X SDS-PAGE sample buffer (Tech&Innovation, Chuncheon, Korea