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Metcalf JP, Thompson AB, Gossman GL, Nelson KJ, Koyama S, Rennard SI, et al

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Journal of cosmetic dermatology, 21(2), 802813

6 Conclusions A new form of cell death, termed ferroptosis, was initially characterized in 2012 as distinct from apoptosis and autophagy

The study also included a catalytically inactive C145A M pro mutant (lacking the active site cysteine), which was also used as a bait protein, in order to discriminate false positives that might bind non-specifically to the M pro active site cysteine via disulfide bond formation