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In Port Tobacco specifically, there were likely enslaved individuals working on plantations and in households, contributing to the local economy and the wealth of slaveholders

The Nicotiana rustica species was commonly used by American Indians and may still be used for ceremonial purposes in some areas

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In this context, the Barker hypothesis provides a compelling framework for understanding how early-life exposures, particularly to maternal behaviors such as smoking, can program biological systems in ways that affect long-term health outcomes