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However, notably in a PCP model of schizophrenia, only 30 mg/kg, but not 3 or 10 mg/kg, rescued defects in hyperlocomotion and PPI, in stark contrast to cell culture models where lower models were more beneficial (Shirai et al., 2012)

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The rotamer library file was then integrated into Rosetta to ensure that the side-chain conformational space of the pAcF is sampled appropriately during simulations

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