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Naltrexone, in a very low dose (typically 1.5 to 4.5 mg), briefly blocks opioid receptors in the brain and on immune cells for a few hours overnight

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Long-term results depend on overall behavior change, not just injection use

Referral thresholds are broadly guided by NICE but may vary according to local NHS Integrated Care System (ICS) policies

These properties make it a compound of significant interest in metabolic research and the study of adipogenesis pathways