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Smoking can: Raise triglycerides (a type of fat in your blood) Lower good cholesterol (HDL) Make blood sticky and more likely to clot, which can block blood flow to the heart and brain Damage cells that line the blood vessels Increase the buildup of plaque (fat, cholesterol, calcium, and other substances) in blood vessels Cause thickening and narrowing of blood vessels Take Action Smoking is the most preventable cause of premature death in the United States