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Patients should inform their healthcare provider of all medications they are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements, to assess any potential interactions

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Briefly, ATDC5 cells were treated twice with 0.1 M Dox (48 h treatment interval), and senescent chondrocytes were established after 4 days of stimulation

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The protein can also cause apoptosis (cellular suicide), and in senescent cells, FOXO4 communicates with p53 to prevent this