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The first is that the longest I-helix in the CYP450 molecule is broken up into two parts, the N-terminal part pulling away from the center of the molecule, and the other is the position of the B-C loop at the top of the molecule producing an open substrate access channel [25]

[31:36] My approach is that I basically start with a diagnostic workup so I can really understand where in that pentad or octad I can start to try to treat

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It combines gas-like diffusivity and liquid-like solvating power, enabling fast and efficient separation of non-polar to moderately polar compounds

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