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Exposure to UV rays, smoke, and pollution stimulates inflammation

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An extension phase (NCT06780449) will assess longer-term outcomes

Elevated plasma and platelet cGAMP levels in cecal ligation and puncture (CLP)-operated mice activate STING palmitoylation by stimulating its interaction with STXBP2, triggering SNARE complex formation, granule secretion, and platelet activation

Four in 5 Americans (80%) indicated they would ask for a simple medical test to detect Alzheimer's rather than waiting for a doctor to suggest it (Figure 23, right panel)