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Final Thoughts Pharmacovigilance is more than a compliance requirementits a crucial pillar of patient safety in clinical trials

Psychiatry 55 : 165171 (2004)

DHODH tangoing with GPX4 on the ferroptotic stage

Simultaneously, hydrogen selenide (H 2 Se) generated from the metabolism of dietary selenium species is converted into selenophosphate (H 2 SePO 3 ) by the enzyme selenophosphate synthetase 2 (SEPHS2) which is then used as a substrate by the enzyme O-phosphoseryl-tRNA [Ser]Sec selenium transferase to incorporate selenium into phosphoseryl-tRNA [Ser]Sec to form Sec-tRNA [ser]sec

These side effects are usually temporary and resolve after a short period