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In reality, both molecules are essential and focusing on one may leave gaps in your cellular system

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When SHMT1 was knocked down in lung cancer cells, SHMT2 and SHMT2 were selectively upregulated [108]

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On the other hand, the free energy generated during glycolysis forms the high-energy compound ATP, which in turn is engaged in maintaining the cellular ionic concentration gradient and the turnover of proteins, lipids, and nucleic acids [65]