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We employed diamide, an established thiol-oxidizing agent that oxidizes GSH to GS-SG [22], to induce GSR-mediated NADPH consumption during reduction of GS-SG back to GSH (Fig 1A)

When delivered through IV, magnesium rapidly crosses the blood-brain barrier, often creating a noticeable calming effect within minutes

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Mol Med Today 2:106113 Abbott NJ, Ronnback L, Hansson E (2006) Astrocyte-endothelial interactions at the blood-brain barrier