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Thrombin also functions as an anticoagulant when bound to thrombomodulin, a receptor protein expressed on the surface of the vascular endothelium, with thrombin-thrombomodulin binding ultimately leading to fibrinolysis

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Yet, it is not just an issue of the end-consumer alone

Multiple logistic regression for the prevalence of respiratory and allergic diseases by tobacco use types The results of logistic regression analyses for the prevalence of chronic respiratory diseases according to tobacco use type are shown in Table 3