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Acid-cleavable linkers [1] Disulfide bonds represent another critical category of chemically cleavable linker s (Figure 4), utilized in three approved ADCs (Mylotarg, Besponsa, and Elahere)

Computational and mutational analysis of human glutaredoxin (thioltransferase): probing the molecular basis of the low pKa of cysteine 22 and its role in catalysis

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A., Ly, K

Understanding that architectural difference multi-molecule combination versus multi-target single molecule is the key to understanding how these three relate and why a researcher might choose one over another