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The samples of the epidermis and SC were obtained from volar forearms, where the influence of other factors such as UV radiation or direct exposure to secondhand smoke from burning cigarettes and exhalation is minimized

After product use, CSs had significantly lower values than ECs (p = 0.001) and NSs (p = 0.0003)

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Both types of smoke contain carcinogens and particulate matter that promotes inflammatory immune responses that may enhance the carcinogenic effects of the smoke

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