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Impaired ( S )-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

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Again, human data is limited, but those with cancer history should exercise particular caution

It may be related to toxicity, oxidative damage, poor nutritional status or nutritional deficiencies, heavy metal or environmental toxicity, systemic disorders, hormonal imbalances, xenobiotic exposure, age-related decline, or obesity

Varicose veins develop when venous valves fail and vein walls lose elasticity due to collagen degradation, chronic inflammation, and impaired endothelial function