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Several research groups have attempted to delineate the underlying mechanisms of irAEs, as curated by the authors of the Cancer Immunology Research paper below

Improved Anchoring: Clinical observation noted an increase in the "anchoring" strength of hair shafts due to a healthier scalp extracellular matrix

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The 2024 review in Pharmaceuticals concluded that "clinical trial evidence for L-arginine or L-Citrulline in chronic blood pressure reduction in the general population requires an examination of trial designs, as not all translational studies may have influenced vascular reactivity." Reasonable medical professionals reviewing this evidence category would reach different conclusions about the appropriate role for these supplements - that's an honest characterization of where the science stands