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While the FDA delayed this review requirement until 2022 for e-cigarettes that were already on the market as of August 8, 2016, the premarket review requirement still applies to new or changed products introduced after August 8, 2016, and it is those products that this letter addresses

The single exception to this pattern was found among males aged 18 to 25

They had been recruited into the SSS from existing cohort studies: 1) the Singapore Population Health Studies (SPHS) cohort first follow-up study and Multi-Ethnic Cohort Phase 3 study

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The company has recently experienced a clear and growing interest from EU-based tobacco companies in its product