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Conducting First-in-Human clinical trials presents notable challenges due to their role as the initial Phase 1 studies, emphasising the importance of careful design and prioritising participant safety

GSTM1 contributes to detoxifying many pollutants and smoke-derived toxins, so the null genotype can increase sensitivity to air pollution, tobacco smoke, and some chemicals

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Detoxification is especially important when it comes to removing heavy metals like mercury, which can linger in brain tissue and contribute to neurological disorders

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