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It seems to be a consensus that OS has been implicated in the pathogenesis of multiple disease states and may be a common pathogenic mechanism of many major psychiatric disorders [101], including AD [99,102,103,104,105], depression [101,103,106,107,108], ALS [109,110,111,112,113], peripheral nervous system diseases [114,115,116], etc

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A unidirectional paradigm proves inadequate

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