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Proteomic analysis showed that these significantly differentially expressed proteins are involved primarily in metabolic pathways including carbon metabolism, amino acid biosynthesis, pyruvate metabolism, glucagon signaling, pentose phosphate pathway, HIF-1 signaling and glycolysis/gluconeogenesis (Figure 4C)

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183 Tumor-associated macrophages (TAMs) often polarize toward the M2 phenotype, which is characterized by immunosuppressive properties that facilitate tumor growth, invasion, and metastasis

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