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56 At the state level, a 10-year longitudinal study conducted among adolescent Victorians published in 2010 found that symptoms of depression and anxiety predicted progression to nicotine dependence well beyond the secondary school years for adolescent smokers

Future research should examine possible improvements to definitions which include intensity of use (e.g., number of puffs per day) and persistence/duration of use, either via self-report or technology-assisted data capture

(2) Druggability and chronic dosing toxicity risks: Most UPS-targeted candidates suffer from common druggability issues such as low solubility, poor membrane permeability and insufficient metabolic stability (Wu et al

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