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The most common side effect is mild soreness or redness at the injection site, and reactions like dizziness or allergy are rare

Nausea management Marketing materials frequently claim b12 reduces nausea associated with semaglutide use

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Prolonged overdose of B6 (150-200 mg/day) over weeks can cause severe sensory-nervous-system dysfunction and ataxia.37 With normal usage serious adverse effects are not reported for pyridoxine (vitamin B6), however, diarrhoea, emesis and rosacea-like dermatitis may be observed in some cases (38)