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Comprehensive transcriptomic analysis revealed relatively low expression levels in both the control and single-natural product groups

3 While several proteins have been shown to regulate ferroptosis, glutathione peroxidase 4 (GPX4) is the central enzyme of this pathway

Similarly, a single intracerebral injection of CRISPR-LNPs targeting PLK1 (sgPLK1-cLNP) enabled in vivo editing of 70% of genes in aggressive orthotopic glioblastoma cells, induced tumor cell apoptosis, inhibited tumor growth by 50%, and increased survival by 30% [293]

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