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Liu Y, Song Z, Liu Y, Ma X, Wang W, Ke Y, et al

1,13 Metformin often causes gastrointestinal side effects (eg, gas and diarrhea)

81,143,144,145 Even though the overexpression of enzymes involved in both the synthesis and breakdown of H 2 S has thus far only been reported for colorectal cancer, 134 it can be envisaged that overexpression of both enzymatic pathways might be a common trait for any cancer type where H 2 S production is increased, as excess H 2 S can become toxic even for the most robust cancer cells (see below)