They contain over 4,000 chemicals over 50 of which are known to be toxic in nature: the carbon monoxide also found in car exhaust fumes, butane found in lighter fluid, and arsenic, ammonia, and methanol found in rocket fuel, for example
The Washington Post
Heart rate was highest when tobacco was combined with cannabis, while there was a moderate increase in blood pressure among participants who combined the drugs, which the researchers say could add to the cardiovascular risk of smoking cannabis
2001 Clearing the smoke: assessing the science base for tobacco harm reduction Washington, DC: National Academy Press Swain PA, Schad VC, Greeenstein JL, Exley MA, Fox BS, Powers SP, Gefter ML
Smoking behaviour as a predictor of depression among Finnish men and women: a prospective cohort study of adult twins